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Jens D Mikkelsen Selected Research

Tesofensine

9/2013Tesofensine induces appetite suppression and weight loss with reversal of low forebrain dopamine levels in the diet-induced obese rat.
6/2010The novel triple monoamine reuptake inhibitor tesofensine induces sustained weight loss and improves glycemic control in the diet-induced obese rat: comparison to sibutramine and rimonabant.
6/2010Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of alpha1 adrenoceptor and dopamine D1 receptor pathways in the diet-induced obese rat.
1/2007Expression of brain derived neurotrophic factor, activity-regulated cytoskeleton protein mRNA, and enhancement of adult hippocampal neurogenesis in rats after sub-chronic and chronic treatment with the triple monoamine re-uptake inhibitor tesofensine.

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Jens D Mikkelsen Research Topics

Disease

21Schizophrenia (Dementia Praecox)
03/2020 - 06/2007
15AIDS-Related Complex (ARC)
10/2014 - 08/2006
9Alzheimer Disease (Alzheimer's Disease)
03/2020 - 01/2010
4Obesity
09/2013 - 01/2009
3Seizures (Absence Seizure)
01/2022 - 02/2006
3Cognitive Dysfunction
12/2019 - 04/2015
3Body Weight (Weight, Body)
09/2011 - 06/2010
2Pain (Aches)
06/2022 - 02/2005
2Inflammation (Inflammations)
06/2022 - 01/2016
2Epilepsy (Aura)
01/2022 - 02/2006
2Temporal Lobe Epilepsy
01/2022 - 01/2022
2Parkinson Disease (Parkinson's Disease)
01/2021 - 01/2016
2Neurodegenerative Diseases (Neurodegenerative Disease)
01/2016 - 04/2015
2Catalepsy
11/2014 - 01/2009
2Weight Loss (Weight Reduction)
09/2013 - 06/2010
2Narcolepsy
06/2013 - 01/2007
2Hypernatremia
12/2008 - 12/2008
1Low Back Pain (Lumbago)
06/2022
1Nervous System Diseases (Neurological Disorders)
01/2022
1Mental Disorders (Mental Disorder)
03/2020
1Brain Injuries (Brain Injury)
06/2016
1Traumatic Brain Injuries (Traumatic Brain Injury)
06/2016
1Contusions
06/2016
1Brain Diseases (Brain Disorder)
01/2016
1Glioblastoma (Glioblastoma Multiforme)
09/2015
1Lordosis
08/2013
1Psychotic Disorders (Schizoaffective Disorder)
05/2013
1Neuroinflammatory Diseases
10/2012
1Chronic Pain
05/2012
1Bipolar Disorder (Manic Depressive Psychosis)
11/2011
1Major Depressive Disorder (Major Depressive Disorders)
11/2011

Drug/Important Bio-Agent (IBA)

17Messenger RNA (mRNA)IBA
06/2022 - 08/2006
15Proteins (Proteins, Gene)FDA Link
01/2022 - 02/2006
15Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA
03/2020 - 05/2007
6Antipsychotic Agents (Antipsychotics)IBA
12/2015 - 01/2009
5Pharmaceutical PreparationsIBA
03/2020 - 06/2007
4Biomarkers (Surrogate Marker)IBA
06/2022 - 02/2010
4Phencyclidine (Angel Dust)IBA
10/2016 - 01/2010
4TesofensineIBA
09/2013 - 01/2007
3KisspeptinsIBA
10/2014 - 07/2013
3Serotonin (5 Hydroxytryptamine)IBA
02/2014 - 02/2005
3Brain-Derived Neurotrophic Factor (BDNF)IBA
06/2013 - 01/2007
3SSR180711IBA
12/2010 - 05/2007
3ParvalbuminsIBA
12/2010 - 05/2009
2Kainic Acid (Kainate)IBA
01/2022 - 03/2006
2Glycoproteins (Glycoprotein)IBA
01/2022 - 01/2022
2Oxidopamine (6 Hydroxydopamine)IBA
01/2021 - 01/2016
2Hormones (Hormone)IBA
01/2016 - 08/2013
2Cholinergic Agents (Cholinergics)IBA
12/2015 - 04/2015
2AntigensIBA
04/2015 - 01/2007
2Peptides (Polypeptides)IBA
10/2014 - 07/2013
2LeptinIBA
12/2013 - 09/2011
2Dopamine (Intropin)FDA LinkGeneric
09/2013 - 01/2009
2activity regulated cytoskeletal-associated proteinIBA
07/2013 - 08/2006
25-HT2A Serotonin Receptor (5 HT2A Receptor)IBA
05/2013 - 01/2010
2N-Methylaspartate (NMDA)IBA
06/2011 - 01/2010
2SynaptophysinIBA
12/2010 - 05/2009
2OrexinsIBA
01/2007 - 09/2004
1CationsIBA
06/2022
1TRPC6 Cation ChannelIBA
06/2022
1Levetiracetam (Keppra)FDA LinkGeneric
01/2022
1RNA (Ribonucleic Acid)IBA
01/2022
1N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
10/2016
1gamma-Aminobutyric Acid (GABA)IBA
10/2016
1Aminobutyrates (Aminobutyric Acid)IBA
10/2016
1Glucagon-Like Peptide 1 (GLP 1)IBA
01/2016
1Exenatide (Byetta)FDA Link
01/2016
1LiraglutideFDA Link
01/2016
1NeurotoxinsIBA
01/2016
1Ligand-Gated Ion ChannelsIBA
09/2015
16- chloro- 2- (4'- iodophenyl)- 3- (N,N- diethyl)imidazo(1,2- a)pyridine- 3- acetamideIBA
09/2015
1acetamideIBA
09/2015
1Amino AcidsFDA Link
09/2015
1pyridineIBA
09/2015
1GadoliniumIBA
09/2015
1Carrier Proteins (Binding Protein)IBA
04/2015
1SteroidsIBA
10/2014
1Neurokinin BIBA
10/2014
1Gonadotropin-Releasing Hormone (GnRH)FDA Link
10/2014
1salicylhydroxamic acid (SHAM)IBA
10/2014
1Dynorphins (Dynorphin)IBA
10/2014
1NeuropeptidesIBA
10/2014
1Glutamic Acid (Glutamate)FDA Link
02/2014
1Estradiol (Delestrogen)FDA LinkGeneric
12/2013
1GonadotropinsIBA
08/2013
1Environmental Pollutants (Pollutants, Environmental)IBA
07/2013
1mancozebIBA
07/2013
1PesticidesIBA
07/2013
1Gonadal Steroid Hormones (Sex Hormones)IBA
07/2013
1Amyloid beta-PeptidesIBA
07/2013
1Nerve Growth Factor (NGF)IBA
06/2013
1Early Growth Response Protein 2IBA
05/2013
1Lysergic Acid Diethylamide (LSD)IBA
05/2013
14-iodo-2,5-dimethoxyphenylisopropylamine (DOI-P)IBA
05/2013
1NicotineFDA Link
10/2012
1Proto-Oncogene Proteins c-fos (FRAs)IBA
08/2012
1LigandsIBA
05/2012
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
06/2011

Therapy/Procedure

2Obesity Management
09/2013 - 06/2010
1Ovariectomy (Oophorectomy)
10/2014